Evolution and Transmission of Cefiderocol-Resistant <i>Acinetobacter baumannii</i> During an Outbreak in the Burn Intensive Care Unit
Steven Smoke, Alison Brophy, Samuel Reveron, Alina Iovleva, Ellen G Kline, Michael A. Marano, Lincoln P. Miller, Ryan K. Shields
Abstract
We report on 11 critically ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and interpatient transmission of cefiderocol-resistant A. baumannii. Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.
Topics & Concepts
Acinetobacter baumanniiOutbreakMedicineAcinetobacterTransmission (telecommunications)Intensive care unitIntensive care medicineMicrobiologyPseudomonas aeruginosaBiologyVirologyBacteriaAntibioticsGeneticsEngineeringElectrical engineeringAntibiotic Resistance in BacteriaVibrio bacteria research studiesBacterial biofilms and quorum sensing