Pyrotinib plus capecitabine for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases (PERMEATE): a multicentre, single-arm, two-cohort, phase 2 trial
Min Yan, Quchang Ouyang, Tao Sun, Limin Niu, Jin Yang, Li Li, Yuhua Song, Chunfang Hao, Zhanhong Chen, Armando Orlandi, Naohiro Ishii, Kazuaki Takabe, Gianluca Franceschini, Francesco Ricci, Claire Verschraegen, Zhenzhen Liu, Mengwei Zhang, Huimin Lv, Liping Liu, Xiaohong Yang, Huawu Xiao, Zhichao Gao, Xiaorui Li, Fangyuan Dong, Xiuchun Chen, Jianghua Qiao, Guifang Zhang
Topics & Concepts
CapecitabineMedicineOncologyInternal medicineBreast cancerHuman Epidermal Growth Factor Receptor 2Translation (biology)Phases of clinical researchEpidermal growth factor receptorHuman breastClinical trialCancerMetastatic breast cancerCancer researchPhase (matter)Growth factor receptorEpidermal growth factorReceptorLung Cancer Treatments and MutationsHER2/EGFR in Cancer ResearchBrain Metastases and Treatment