Mesenchymal stem cells for regenerative medicine in central nervous system
Man Li, Hong Chen, Mingxin Zhu
Abstract
Mesenchymal stem cells (MSCs) are multipotent stem cells, whose paracrine and immunomodulatory potential has made them a promising candidate for central nervous system (CNS) regeneration. Numerous studies have demonstrated that MSCs can promote immunomodulation, anti-apoptosis, and axon re-extension, which restore functional neural circuits. The therapeutic effects of MSCs have consequently been evaluated for application in various CNS diseases including spinal cord injury, cerebral ischemia, and neurodegenerative disease. In this review, we will focus on the research works published in the field of mechanisms and therapeutic effects of MSCs in CNS regeneration.
Topics & Concepts
Mesenchymal stem cellNeuroscienceRegenerative medicineRegeneration (biology)Paracrine signallingCentral nervous systemSpinal cord injuryStem cellNeural stem cellMedicineBiologySpinal cordPathologyCell biologyReceptorInternal medicineMesenchymal stem cell researchSpinal Cord Injury ResearchNerve injury and regeneration