Capsule Promotes Intracellular Survival and Vascular Endothelial Cell Translocation during Invasive Pneumococcal Disease
Terry Brissac, Eriel Martínez, Katherine L. Kruckow, Ashleigh N. Riegler, Feroze Ganaie, Hansol Im, Sayan Bakshi, Nicole M. Arroyo-Díaz, Brady L. Spencer, Jamil S. Saad, Moon H. Nahm, Carlos J. Orihuela
Abstract
Streptococcus pneumoniae ( Spn ) is the leading cause of invasive disease. Importantly, only a subset of the 100 capsule types carried by Spn cause the majority of serious infections, suggesting that the biochemical properties of capsular polysaccharide are directly tied to virulence.
Topics & Concepts
IntracellularChromosomal translocationCellDiseasePneumococcal diseaseEndothelial stem cellImmunologyBiologyMedicineMicrobiologyCell biologyStreptococcus pneumoniaePathologyIn vitroGeneticsAntibioticsGenePneumonia and Respiratory InfectionsPleural and Pulmonary DiseasesChronic Obstructive Pulmonary Disease (COPD) Research