Ruthenium-Catalyzed Isomerization of <i>ortho</i>-Silylanilines to Their <i>para</i> Isomers
Wataru Ishiga, Masaya Ohta, Takuya Kodama, Mamoru Tobisu
Abstract
The catalytic ortho to para transposition of a silyl group in aniline derivatives is described. [RuCl2(p-cymene)]2/BINAP in conjunction with a Cu(OAc)2 additive serves as a potent catalytic system. This method is also applicable to the isomerization of 2-silylpyrrole derivatives to the corresponding 3-silyl isomers.
Topics & Concepts
IsomerizationChemistrySilylationRutheniumCatalysisAnilineMedicinal chemistryOrganic chemistrySynthetic Organic Chemistry MethodsChemical Synthesis and AnalysisOrganoboron and organosilicon chemistry