Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production
Koichiro Kawaguchi, Kaori Komoda, Ryuta Mikawa, Azusa Asai, Masataka Sugimoto
Abstract
, and gene expression profiling revealed that seCad induced genes associated with poor prognosis in patients with melanoma. An analysis of sera from patients revealed that serum seCad is associated with distant metastasis. Our data suggest that senescent cells promote metastatic lung cancer through seCad, and that seCad may be a potential diagnostic marker as well as a therapeutic target for metastatic lung cancer.
Topics & Concepts
SenescenceMetastasisCellular senescenceCancer metastasisCancerCadherinCancer cellCell biologyChemistryCancer researchBiologyBiochemistryGeneticsPhenotypeGeneCellTelomeres, Telomerase, and SenescenceMechanisms of cancer metastasisEpigenetics and DNA Methylation