Vascular endothelial growth factor-tyrosine kinase inhibitors: Novel mechanisms, predictors of hypertension and management strategies
Javier Gómez
Abstract
Vascular endothelial growth factor inhibition has become a cornerstone of cancer therapy. Significant adverse effect is associated with these therapies, with hypertension among the most prevalent. We aim to provide a current review of the mechanisms by which these therapies induce hypertension, the risk factors and predictors of the development of hypertension, and management strategies to minimize the risk of cardiovascular complications in patients receiving vascular endothelial growth factor inhibition as part of cancer treatment.
Topics & Concepts
MedicineVascular endothelial growth factorRisk factorTyrosine kinaseAdverse effectInternal medicineTyrosine-kinase inhibitorCancerVEGF receptorsReceptorAngiogenesis and VEGF in CancerChemotherapy-induced cardiotoxicity and mitigationCancer, Stress, Anesthesia, and Immune Response