The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration
Carl Randall Harrell, Valentin Djonov, Vladislav Volarević
Abstract
Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.
Topics & Concepts
Mesenchymal stem cellCell biologyJuxtacrine signallingRegeneration (biology)Paracrine signallingImmune systemStem cellBiologyStem cell transplantation for articular cartilage repairMultipotent Stem CellImmunologyAdult stem cellEndothelial stem cellIn vitroProgenitor cellBiochemistryReceptorMesenchymal stem cell researchIL-33, ST2, and ILC PathwaysMicroRNA in disease regulation