The efficacy of Akkermansia muciniphila YGMCC2602-derived postbiotics in skin repair
Zhili He, Wenfang Song, Shi-Chang Zhang, Minlei Zhao, Fan Wang, Shanshan He, Xiaochi Jie, Qi Gao, Jianguo Chen
Abstract
Skin aging, wrinkles, dryness, and inflammation have been of great concern and the development of non-toxic natural skin care products is of great importance. In this study, we investigated for the role of three postbiotics (cell-free supernatant, bacterial lysate, and extracellular vesicles) from Akkermansia muciniphila YGMCC2602 in skin health. In vitro experiments showed that these postbiotics promoted HSF cell proliferation and migration, and upregulated the expression of collagen ( COL17A1 , COL1A1 , COL3A1 ) and hyaluronan synthase ( HAS1 ). The bacterial lysate and extracellular vesicles also attenuated ultraviolet B-induced inflammation, reactive oxygen species accumulation, and apoptosis in HaCaT Cells, thereby mitigating photodamage. In addition, the bacterial lysate exhibited immunosuppressive effects in lipopolysaccharides-induced Raw 264.7 cells and alleviated skin redness and water loss, while increasing stratum corneum moisture content in human skin. In summary, the bacterial lysate of YGMCC2602 significantly alleviated skin aging, dryness, and inflammation, providing a candidate ingredient for skin care or functional food.