Elucidating the Therapeutic Mechanisms of Agrimonia pilosa Ledeb. Extract for Acute Myocardial Infarction via Network Pharmacology and Experimental Validation
Elias Njoroge, Samuel Odhiambo
Abstract
This study aimed to uncover the mechanisms by which Agrimonia pilosa Ledeb. (APL) extract mitigates acute myocardial infarction (AMI) using a combination of network pharmacology and experimental validation. The main bioactive constituents of APL extract were identified through High-Performance Liquid Chromatography (HPLC). Potential targets shared between APL compounds and AMI were predicted via network pharmacology. An AMI model in mice was induced by subcutaneous isoproterenol (Iso) injection,
Topics & Concepts
PharmacologyMyocardial infarctionMedicineSystems pharmacologyTraditional medicineBiological activityDrugAnimal modelMechanism of actionChemistryCardiac Fibrosis and RemodelingCardiac Ischemia and ReperfusionCardiovascular Function and Risk Factors