Mangiferin alleviates trimethylamine-<i>N</i>-oxide (TMAO)-induced atherogenesis and modulates gut microbiota in mice
Zouyan He, Hanyue Zhu, Jianhui Liu, Erika Kwek, Ka Ying, Zhen‐Yu Chen
Abstract
. This modulation led to a decrease in plasma lipopolysaccharide levels, enhanced the production of total SCFAs by gut microbes, and reduced susceptibility to atherosclerosis. In conclusion, mangiferin exhibited its ability to alleviate TMAO-induced atherosclerosis through its anti-inflammatory, cholesterol-lowering, and gut microbial modulatory activities.
Topics & Concepts
Trimethylamine N-oxideGut floraMangiferinChemistryTrimethylaminePharmacologyBiologyBiochemistryMangiferin and Mango Extracts