Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage
Bozhi Ye, Xiaowen Shi, Jianjiang Xu, Shanshan Dai, Jiajun Xu, Xiaoxi Fan, Bingjiang Han, Jibo Han
Topics & Concepts
PyroptosisCardiotoxicityDoxorubicinProgrammed cell deathPharmacologyApoptosisCell biologyMedicineChemistryCancer researchBiologyToxicityChemotherapyBiochemistryInternal medicineInflammasome and immune disordersChemotherapy-induced cardiotoxicity and mitigationCalcium signaling and nucleotide metabolism