Immunoinformatics-guided design of a multi-epitope vaccine based on the structural proteins of severe acute respiratory syndrome coronavirus 2
Ahmad J. Obaidullah, Mohammed M. Alanazi, Nawaf A. Alsaif, Hussam Albassam, Abdulrahman A. Almehizia, Ali Alqahtani, Shafi Mahmud, Saad Ahmed Sami, Talha Bin Emran
Abstract
K12, was used to determine the GC content and the codon adaptation index (CAI) value, which further followed for the incorporation into the cloning vector pET28+(a). Collectively, these findings suggested that the constructed vaccine could be used to modulate the immune reaction against SARS-CoV-2.
Topics & Concepts
EpitopeCoronavirusCoronavirus disease 2019 (COVID-19)VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Respiratory tractRespiratory systemMedicineRespiratory tract infections2019-20 coronavirus outbreakImmunologyAntibodyPathologyDiseaseInternal medicineOutbreakInfectious disease (medical specialty)vaccines and immunoinformatics approachesMonoclonal and Polyclonal Antibodies ResearchSARS-CoV-2 and COVID-19 Research