Amino acid-based H<sub>2</sub>S donors: <i>N</i>-thiocarboxyanhydrides that release H<sub>2</sub>S with innocuous byproducts
Kuljeet Kaur, Patrick Enders, Yumeng Zhu, Abigail F. Bratton, Chadwick R. Powell, Khosrow Kashfi, John B. Matson
Abstract
A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.
Topics & Concepts
Amino acidChemistryStereochemistryBiochemistrySulfur Compounds in BiologyAdenosine and Purinergic SignalingSulfur-Based Synthesis Techniques