A versatile inhibitory approach and molecular mechanism on cancer cells and cholinesterase enzymes: Synthesis, DFT, ADMET and molecular docking of thiadiazole and oxadiazole derivatives
Tayyiaba Iqbal, Shoaib Khan, Rafaqat Hussain, Yousaf Khan, Fazal Rahim, Azam Hayat, Nasser S. Awwad, Ali G. Alkhathami
Topics & Concepts
ChemistryOxadiazoleEnzymeCholinesteraseDocking (animal)Mechanism (biology)Combinatorial chemistryInhibitory postsynaptic potentialStereochemistryBiochemistryOrganic chemistryPharmacologyNeuroscienceBiologyEpistemologyPhilosophyMedicineNursingComputational Drug Discovery MethodsSynthesis and biological activityCholinesterase and Neurodegenerative Diseases