Antimicrobials from human skin commensal bacteria protect against <i>Staphylococcus aureus</i> and are deficient in atopic dermatitis
Teruaki Nakatsuji, Tiffany H. Chen, Saisindhu Narala, Kimberly Chun, Aimee Two, Yun Tong, Faiza Shafiq, Paul F. Kotol, Amina Bouslimani, Alexey V. Melnik, Haythem Latif, Ji-Nu Kim, Alexandre Lockhart, Keli Artis, Gloria L. David, Patricia A. Taylor, Joanne E. Streib, Pieter C. Dorrestein, Alex Grier, Steven R. Gill, Karsten Zengler, Tissa Hata, Donald Y.M. Leung, Richard L. Gallo
Abstract
These findings show how commensal skin bacteria protect against pathogens and demonstrate how dysbiosis of the skin microbiome can lead to disease.
Topics & Concepts
Staphylococcus aureusAtopic dermatitisAntimicrobialStaphylococcal Skin InfectionsMicrobiologySkin infectionBacteriaStaphylococcusMedicinePathogenic bacteriaAntimicrobial peptidesColonizationImmunologyBiologyGeneticsDermatology and Skin DiseasesAntimicrobial Peptides and ActivitiesFood Allergy and Anaphylaxis Research