Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-κB, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages
María Luisa Castejón, Tatiana Montoya, Juan Ortega‐Vidal, Joaquı́n Altarejos, Catalina Alarcón‐de‐la‐Lastra
Abstract
studies are warranted to further investigate the bioactivity of this interesting compound that might be a promising natural agent for the treatment of immune-inflammatory diseases.
Topics & Concepts
ChemistrySignal transductionHeme oxygenaseNitric oxide synthaseKinaseJanus kinaseWestern blotJanus kinase 2Molecular biologyNitric oxideBiochemistryCell biologyHemeBiologyEnzymeGeneOrganic chemistryCholesterol and Lipid MetabolismPhytochemical Studies and BioactivitiesGenomics, phytochemicals, and oxidative stress