The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities
Tashinga E. Bapiro, Scott E. Martin, Stephen Wilkinson, Alexandra L. Orton, Niresh Hariparsad, Stephanie Harlfinger, Dermot F. McGinnity
Topics & Concepts
MicrosomeAldehyde oxidaseCytochrome P450MonooxygenaseCytosolFlavin-containing monooxygenaseOxidase testCYP3AMetaboliteMetabolismChemistryBiochemistryStereochemistryBiologyEnzymeXanthine oxidasePharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsAnalytical Chemistry and Chromatography