Rh(III)-Catalyzed [3 + 2] Spirocyclization of 2<i>H</i>-Imidazoles with 1,3-Diynes for the Synthesis of Spiro-[imidazole-indene] Derivatives
Yi Luo, Hao Liu, Jing Zhang, Man Liu, Lin Dong
Abstract
An effective strategy to synthesize spirocyclic compounds, [imidazole-4,1′-indene], has been efficaciously developed relied on Rh(III)-catalyzed [3 + 2] spirocyclization of 2H-imidazoles and 1,3-diynes with excellent chemselectivity and regioselectivity. This protocol shows a straightforward way to construct the versatile spirocyclic compounds with wide functional group compatibility, high atom economy, and diverse functionalization of products.
Topics & Concepts
ChemistryImidazoleRegioselectivityIndeneCatalysisCombinatorial chemistrySurface modificationStereochemistryMedicinal chemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCatalytic Cross-Coupling Reactions