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Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Zhi‐Jiang Jiang, Si-Han Xu, Yuhang Su, Erxun Hu, Jiawei Han, Jian‐Fei Bai, Bencan Tang, Jia Chen, Zhanghua Gao

2023Chemical Communications16 citationsDOI

Abstract

as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.

Topics & Concepts

RegioselectivityCatalysisNickelDeuteriumChemistryAcetoneHydrogenKinetic isotope effectHydrogen–deuterium exchangeOrganic chemistryPhysicsQuantum mechanicsChemical Reactions and IsotopesMuon and positron interactions and applicationsHydrogen Storage and Materials
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