Hexamethyldisilazane-Mediated Amidination of Sulfonamides and Amines with Formamides
Yu-Chen Chou, Wei‐Han Lin, Xiu-Yi Lin, Chin-Ling Kuo, Wan‐Qin Zeng, I‐Chung Lu, Chien‐Fu Liang
Abstract
-disubstituent formimidamide, after which a reaction with sulfonamides was induced to form sulfonylformamidines. This protocol can be applied for arylformamidine formation in which anilines are used as substrates under optimized conditions. The advantages of this method are high efficiency, structural diversity in products with good yields, and applicability in large-scale operations.
Topics & Concepts
FormamidesChemistryCombinatorial chemistryReaction conditionsOrganic chemistryComputational chemistryCatalysisSynthesis and Catalytic ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods