NOX4-derived ROS Regulates Aerobic Glycolysis of Breast Cancer through YAP Pathway
Zhenzhen Zhang, Qiu Luan, Wanting Hao, Yan Cui, Yaming Li, Xuena Li
Abstract
NOX4 affects breast cancer glycolysis through ROS-induced activation of the YAP pathway, further promoting the proliferation and migration of breast cancer cells.
Topics & Concepts
NOX4PKM2BlotAnaerobic glycolysisCancer researchCell growthGLUT1BiologyChemistryCancer cellMolecular biologyCancerGlycolysisCell biologyReactive oxygen speciesGlucose uptakeBiochemistryPyruvate kinaseEndocrinologyEnzymeNADPH oxidaseGeneInsulinGeneticsCancer, Hypoxia, and MetabolismHippo pathway signaling and YAP/TAZRNA modifications and cancer