Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe2+ accumulation
Maowei Ni, Jie Zhou, Zhihui Zhu, Qiang Xu, Zhuomin Yin, Yifan Wang, Zhiguo Zheng, Huajun Zhao
Topics & Concepts
CisplatinChemistryViability assayHMOX1In vivoPharmacologyLipid peroxidationCancer researchDownregulation and upregulationReactive oxygen speciesMolecular biologyHeme oxygenaseCellBiologyBiochemistryOxidative stressChemotherapyMedicineHemeEnzymeInternal medicineBiotechnologyGeneFerroptosis and cancer prognosisFerrocene Chemistry and ApplicationsCancer Mechanisms and Therapy