Stem cell niche organization in the Drosophila ovary requires the ECM component Perlecan
Alfonsa Díaz-Torres, Alicia E. Rosales‐Nieves, J. R. A. Pearson, Carmen Santa-Cruz Mateos, Miriam Marín-Menguiano, Owen J. Marshall, Andrea H. Brand, Acaimo González‐Reyes
Abstract
We report that niche architecture in the developing gonad requires trol, that niche cells secrete an isoform-specific Perlecan-rich interstitial matrix, and that DE-cadherin-dependent stem cell-niche adhesion necessitates trol. Hence, we provide evidence to support a structural role for Perlecan in germline niche establishment during larval stages and in the maintenance of a normal pool of stem cells in the adult niche.
Topics & Concepts
BiologyStem cellExtracellular matrixStem cell nicheCell biologyScopusCellGeneticsProgenitor cellBiochemistryMEDLINEInvertebrate Immune Response MechanismsDevelopmental Biology and Gene RegulationNeurobiology and Insect Physiology Research