Binding of the erlin1/2 complex to the third intralumenal loop of IP3R1 triggers its ubiquitin-proteasomal degradation
Xiaokong Gao, Caden G. Bonzerato, Richard J.H. Wojcikiewicz
Abstract
R1 to IL3 and show that the region immediately adjacent to TM5 is key to the events that facilitate channel opening.
Topics & Concepts
Ubiquitin ligaseUbiquitinEndoplasmic reticulumProteasomeMutationCell biologyBiochemistryBiologyInositolChemistryReceptorGeneCellular transport and secretionUbiquitin and proteasome pathwaysEndoplasmic Reticulum Stress and Disease