Natural diterpenoid eriocalyxin B covalently modifies glutathione and selectively inhibits thioredoxin reductase inducing potent oxidative stress-mediated apoptosis in colorectal carcinoma RKO cells
Dongzhu Duan, Yanru Wang, Xiaojie Jin, Mi Li, Le Wang, Yunyun Yan, Jian Xiao, Peng Song, Xiao‐Ling Wang
Topics & Concepts
Thioredoxin reductaseGlutathioneOxidative stressChemistryApoptosisThioredoxinBiochemistryGlutathione reductaseCarcinogenesisPharmacologyCancer researchEnzymeBiologyGeneGlutathione peroxidaseRedox biology and oxidative stressGlutathione Transferases and PolymorphismsDrug Transport and Resistance Mechanisms