Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy
Jun Lu, Xin Ma, Wen‐Cong Gao, Xin Zhang, Yuanling Fu, Qian Liu, Li-Xiang Tian, Xiaodan Qin, Weimin Yang, Hong‐Yi Zheng, Chang‐Bo Zheng
Abstract
) gene, which was found to be highly reversed and downregulated by GAS, served as a core gene linking energy metabolism, immune regulation, and systemic development. Subsequent functional verification demonstrated that IGF2, and its receptor IGF2R, is one of the targets of GAS that helps protect against cardiac hypertrophy. Taken together, we have identified, for the first time, IGF2/IGF2R as a potential target influenced by GAS in the prevention of cardiac hypertrophy.
Topics & Concepts
Downregulation and upregulationInternal medicineAngiotensin IIEndocrinologyMuscle hypertrophyHeart failureGrowth factorReceptorInsulin-like growth factorMedicineBiologyGeneBiochemistrySignaling Pathways in DiseasePlant Molecular Biology ResearchBiological and pharmacological studies of plants