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Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway

Bingtian Xu, Jiangping Xu, Ningbo Cai, Mengfan Li, Lu Liu, Yunyun Qin, Xing Li, Haitao Wang

2020Free Radical Biology and Medicine91 citationsDOI

Topics & Concepts

GSK3BPhosphorylationGSK-3Oxidative stressProtein kinase BKinaseChemistryEndocrinologyInternal medicinePharmacologyMedicineCancer researchCell biologyBiologyBiochemistryNeuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic SignalingPhosphodiesterase function and regulation
Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway | Litcius