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Advancing targeted protein degrader discovery by measuring cereblon engagement in cells

Breanna L. Zerfas, Fidel Huerta, Hu Liu, Guangyan Du, Nathanael S. Gray, Lyn H. Jones, Radosław P. Nowak

2022Methods in enzymology on CD-ROM/Methods in enzymology12 citationsDOI

Topics & Concepts

CereblonLuciferaseChemistryUbiquitin ligaseUbiquitinFusion proteinCell biologyBioluminescenceComputational biologyBiochemistryBiologyGeneRecombinant DNATransfectionProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis
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