Combining structure-based pharmacophore modeling and machine learning for the identification of novel BTK inhibitors
Tanuj Sharma, Venu Venkatarame Gowda Saralamma, Duk‐Chul Lee, Mohammad Imran, Jaehyuk Choi, Mohammad Hassan Baig, Jae-June Dong
Topics & Concepts
Bruton's tyrosine kinasePharmacophoreIn silicoTyrosine kinaseChemistrySignal transductionCancerKinaseCell growthCancer researchCancer cellComputational biologyPharmacologyBiochemistryBiologyGeneticsGeneChronic Lymphocytic Leukemia ResearchBiochemical and Molecular ResearchProtein Degradation and Inhibitors