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Cell cycle checkpoints and beyond: Exploiting the ATR/CHK1/WEE1 pathway for the treatment of PARP inhibitor–resistant cancer

Nitasha Gupta, Tzu‐Ting Huang, Sachi Horibata, Jung‐Min Lee

2022Pharmacological Research108 citationsDOIOpen Access PDF

Topics & Concepts

Wee1CHEK1Cell cycleCell cycle checkpointDNA repairBiologyCancer researchG2-M DNA damage checkpointSynthetic lethalityDNA damageCancerCyclin-dependent kinase 1GeneticsDNAPARP inhibition in cancer therapyDNA Repair MechanismsCRISPR and Genetic Engineering
Cell cycle checkpoints and beyond: Exploiting the ATR/CHK1/WEE1 pathway for the treatment of PARP inhibitor–resistant cancer | Litcius