Morphine- and foot shock-responsive neuronal ensembles in the VTA possess different connectivity and biased GPCR signaling pathway
Fan Wang, C. Liu, Yi Wang, Xixi Wang, Yuan-yao Yang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang
Abstract
Taken together, these findings reveal the heterogeneous connectivity and signaling pathways of the VTA neurons in response to morphine and foot shock, providing new insights for development of specific interventions for psychiatric disorders caused by various stressors associated with different VTA neuronal functions.
Topics & Concepts
Ventral tegmental areaNeuroscienceOptogeneticsDopaminergicDorsal raphe nucleusVentral pallidumDopamineNucleus accumbensBiologyInternal medicineReceptorMedicineSerotonergicBasal gangliaCentral nervous systemSerotoninGlobus pallidusReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior