Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable “click” oxime bond tethers and preclinical evaluation against prostate cancer
Eirinaios I. Vrettos, Theodoros Karampelas, Nisar Sayyad, Anastasia Kougioumtzi, Nelofer Syed, Timothy Crook, Carol Murphy, Constantin Tamvakopoulos, Andreas G. Tzakos
Topics & Concepts
ChemistryGemcitabineLinkerLNCaPProstate cancerCancer researchTumor microenvironmentCancer cellClick chemistryInternalizationFlow cytometryCancerPharmacologyBiochemistryCombinatorial chemistryCellImmunologyInternal medicineBiologyMedicineOperating systemComputer scienceProtein Degradation and InhibitorsChemical Synthesis and AnalysisClick Chemistry and Applications