Gut-derived indole propionic acid alleviates liver fibrosis by targeting profibrogenic macrophages via the gut‒liver axis
Yuanyuan Luo, Yarong Hao, Chunyan Sun, Zhi Lü, Hao Wang, Yuhan Lin, Yaping Guan, Lingyan Cai, Chen‐Hong Ding, Binbin Li, Fei Chen, Yiting Lu, Yong Lin, Xin Zeng
Topics & Concepts
Hepatic stellate cellHepatic fibrosisProinflammatory cytokineChemistryFibrosisMacrophageLiver cytologyPharmacologyKynurenineBiologyCancer researchKupffer cellCirrhosisMyofibroblastLiver fibrosisImmunologyMetabolismTryptophanDownregulation and upregulationSignal transductionKnockout mouseMetabolomicsCell biologyDrug metabolismPathologyPhenotypeLiver Disease Diagnosis and TreatmentLiver physiology and pathologyDrug-Induced Hepatotoxicity and Protection