TRIB3 reduces CD8 <sup>+</sup> T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer
Shuang Shang, Yu-wei Yang, Fei Chen, Liang Yu, Shuohao Shen, Ke Li, Bing Cui, Xiaoxi Lv, Cheng Zhang, Chen Yang, Jing Liu, Jiaojiao Yu, Xiaowei Zhang, Pingping Li, Shengtao Zhu, Haizeng Zhang, Fang Hua
Abstract
TRIB3 promotes exclusion of CD8 + T cells and enhances immune evasion by inhibiting the STAT1-CXCL10 signaling axis in colorectal cancer.
Topics & Concepts
Cancer researchImmune systemSTAT1ImmunotherapyCD8BiologyT cellImmune checkpointSTAT proteinCell biologySignal transductionSTAT3ImmunologyCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionEndoplasmic Reticulum Stress and Disease