Coumarins effectively inhibit bacterial α-carbonic anhydrases
Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty, Claudiu T. Supuran
Abstract
s of 137-948.9 µM for hCA I and of 296.5-961.2 µM for hCA II, respectively. These findings are relevant for discovering coumarin bacterial CA inhibitors with selectivity for the bacterial over human isoform, with potential applications as novel antibacterial agents.
Topics & Concepts
CoumarinChemistryProdrugNeisseria gonorrhoeaeEnzymeBiochemistryCarboxylic acidCarbonic anhydraseKetoneBacteriaStereochemistryRing (chemistry)MicrobiologyBiologyOrganic chemistryGeneticsEnzyme function and inhibitionSynthesis and Catalytic ReactionsChemical Reactions and Mechanisms