Zoledronic Acid Implant Coating Results in Local Medullary Bone Growth
Juliana C. Quarterman, Pornpoj Phruttiwanichakun, Douglas C. Fredericks, Aliasger K. Salem
Abstract
, the Za/PLGA screws were then implanted into the tibiae of Sprague-Dawley rats. After 8 weeks, microCT imaging showed new bone growth along the medullary cavity around the implant site, supporting the local release of ZA to enhance bone growth around the implant. Histological staining further confirmed the presence of new mineralized medullary bone growth resembling the cortical bone. Such local medullary growth represents an opportunity for future studies with alternative coating methods to fine-tune the local release of ZA from the coating and enhance complete osseointegration of the implant.
Topics & Concepts
Medullary cavityZoledronic acidOsseointegrationImplantBisphosphonateBone growthPLGADentistryTitaniumBiomedical engineeringGlycolic acidMedicineChemistrySurgeryOsteoporosisAnatomyIn vitroLactic acidInternal medicineBiologyOrganic chemistryGeneticsBacteriaBiochemistryOrthopaedic implants and arthroplastyBone Tissue Engineering MaterialsBone health and treatments