Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose
Soo-Mi Kweon, Jose Irimia-Dominguez, Gayeoun Kim, Patrick T. Fueger, Kinji Asahina, Keith Lai, Keith Lai, Daniela Allende, Quincy R. Lai, Chih‐Hong Lou, Walter Tsark, Ju Dong Yang, Dominic S. Ng, Ju‐Seog Lee, Patrick Tso, Wendong Huang, Keane K. Y. Lai, Keane K. Y. Lai
Abstract
We have developed and now report on the first functional global midnolin knockout mouse model. We found that global heterozygous midnolin knockout attenuated the severity of nonalcoholic fatty liver disease (NAFLD) in mice fed a Western-style diet, high in fat, cholesterol, and fructose, and this attenuation in disease was associated with significantly reduced levels of large lipid droplets, hepatic free cholesterol, and serum LDL, with significantly differential gene expression involved in cholesterol/lipid metabolism.