Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability
Pui–Kei Wu, Seung‐Keun Hong, Dmytro Starenki, Kiyoko Oshima, Hao Shao, Jason E. Gestwicki, Susan Tsai, Jong‐In Park
Topics & Concepts
BiologyGene knockdownCancer researchKRASProgrammed cell deathMitochondrionApoptosisCell cultureMolecular biologyCell biologyMutationBiochemistryGeneGeneticsHeat shock proteins researchMitochondrial Function and PathologyFOXO transcription factor regulation