Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules
Christopher M. Hickey, Katherine M. Digianantonio, Kurt Zimmermann, Alicia Harbin, Connor Quinn, Avani Patel, Peter C. Gareiss, Amanda Chapman, Bernadette Tiberi, Jennifer Dobrodziej, John Corradi, Angela Cacace, David R. Langley, Miklós Békés
Topics & Concepts
Ubiquitin ligaseDNA ligaseTetramerUbiquitinProteolysisUbiquitin-Protein LigasesSmall moleculeChemistryBiochemistryPlasma protein bindingCell biologyBiologyComputational biologyEnzymeGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis