Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation
Matt J. Barter, Kathleen Cheung, Julia Falk, Andreas Panagiotopoulos, Caitlin Cosimini, Siobhan O’Brien, Karina Teja-Putri, Graham W. Neill, David J. Deehan, David A. Young
Abstract
. These same regions were also accessible for activation using a dCas9-transcriptional activator and showed enhancer activity in a cellular model. Together, these data describe and functionally validate a number of dynamically accessible chromatin regions involved in inflammatory signalling.
Topics & Concepts
BiologyChromatinEnhancerChIA-PETGene expressionTranscription factorRegulation of gene expressionGeneticsEpigenomicsComputational biologyGeneCell biologyChromatin remodelingDNA methylationGenomics and Chromatin DynamicsCRISPR and Genetic Engineeringinterferon and immune responses