Highly Selective 1,4-Diacylation/Cycloisomerization of 1,3-Enynes: <i>De Novo</i> Synthetic Strategy to Polysubstituted Furans

Abstract

synthetic strategy for rapid assembly of biologically relevant multisubstituted furans is an appealing but challenging task. Herein, we disclose NHC and organophotocatalysis cocatalyzed three-component radical 1,4-diacylation/cycloisomerization cascade process of readily available 1,3-enynes, which provides an efficient and straightforward entry to a wide range of polysubstituted furans with good yields and excellent regio- and chemoselectivities. The reaction features mild conditions, broad substrate scopes, and good functional group compatibilities.

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