Suppression of SIRT1/FXR signaling pathway contributes to oleanolic acid-induced liver injury
Songjie Liao, Xiaolong Fu, Jianxiang Huang, Yi Wang, Yuan‐Fu Lu, Shaoyu Zhou
Topics & Concepts
Farnesoid X receptorSirtuin 1Bile acidChemistrySignal transductionPharmacologyMultidrug resistance-associated protein 2Oleanolic acidLiver injuryDownregulation and upregulationNuclear receptorCell biologyEndocrinologyCancer researchBiologyBiochemistryTranscription factorMedicineGeneATP-binding cassette transporterTransporterPathologyAlternative medicinePharmacological Effects of Natural CompoundsNatural product bioactivities and synthesisToxin Mechanisms and Immunotoxins