Access to <i>P</i>-chiral <i>sec</i>- and <i>tert</i>-phosphine oxides enabled by Le-Phos-catalyzed asymmetric kinetic resolution
Haile Qiu, Qiang Dai, Jiafeng He, Wenbo Li, Junliang Zhang
Abstract
Herein we report an efficient kinetic resolution of secondary phosphine oxides <italic>via</italic> a Le-Phos-catalyzed asymmetric allylation reaction with Morita–Baylis–Hillman carbonates.
Topics & Concepts
Kinetic resolutionPhosPhosphineCatalysisKinetic energyChemistryAsymmetric inductionMedicinal chemistryStereocenterResolution (logic)StereochemistryEnantioselective synthesisOrganic chemistryPhysicsBiochemistryArtificial intelligenceQuantum mechanicsComputer scienceAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry Methods