Management of hepatotoxicity of chemotherapy and targeted agents.
Todd William Mudd, Achuta Kumar Guddati
Abstract
Hepatotoxicity of chemotherapeutic agents such as methotrexate, oxaliplatin, and irinotecan have been well documented and characterized allowing for careful management by oncologists during administration. However, the rapid advance of the field of oncology and introduction of new classes of therapies such as small molecule inhibitors and immunotherapies have introduced new hepatotoxicity challenges and management strategies. This work is a compilation of the hepatotoxicity and recommended management of various chemotherapies and targeted agents, with a focus on the newer classes of targeted anticancer agents.
Topics & Concepts
OxaliplatinIrinotecanMedicineMethotrexateChemotherapyPharmacologyTargeted therapyCancer researchInternal medicineCancerColorectal cancerCancer therapeutics and mechanismsDrug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance Mechanisms