Familial component of early-onset colorectal cancer: opportunity for prevention
María Daca-Álvarez, Marc Martí, Antonino Spinelli, Noel F. F. C. de Miranda, Claire Palles, Alfredo Vivas López, Andrew Lachtford, Kevin Monahan, Marek Szczepkowski, Wiesław Tarnowski, Silviu-Tiberiu Makkai-Popa, Rosario Vidal, Irene López, Elena Hurtado, Fernando Jiménez, Marta Jiménez‐Toscano, Edurne Álvaro, Gonzalo Sanz, Araceli Ballestero, Sirio Melone, Lorena Brandáriz, Isabel Prieto, Damián García‐Olmo, Teresa Ocaña, Rebeca Moreira, Lorena Moreno, Sabela Carballal, Leticia Moreira, María Pellisé, Rogelio González‐Sarmiento, Andreana N. Holowatyj, José Perea, Francesc Balaguer, GEOCODE and SECOC consortia, A C Santos, Marı́a Elena Martı́nez, Vı́ctor Moreno, Jose Carlos J C Ruffinelli, L Inglada-Pérez, José A. Rueda, V Castellano, Sergio Hernández‐Villafranca, Manuel Escanciano, Adriana Cavero, V Portugal, María Arriba Domenech, Luís Miguel Jiménez, I Peligros, Craig Mccaff Rey, J Zorrilla, Míriam Cuatrecasas, Ariadna Sánchez, Liseth Rivero, Mar Iglesias, Ana Ramı́rez de Molina, G Colmenarejo, Isabel Espinosa‐Salinas, L Fernández, M Gómez de Cedrón, Luís A. Corchete, Johanny Garcia, Paul Gómez Garcia, Andrea R. Hernandez, Abel Martel-Martel, J. Pérez, Ana Burdaspal, M de Fuenmayor, A Forero, I Rubio, J Fernández, E. Pastor, Aníbal A Villa de Villafañe, O Alonso, S.M. Encinas, A Teijo, Carlos Pastor, Jorge Arredondo, J Baixauli, L Ceniceros, Juana Mari Rodriguez, Celia Morales Sánchez, J Die, J Fernández, Juan Ocaña, J Dziakova, S. Sotos Picazo, Ricardo M Héctor Sanz, M Suárez, José A. Sánchez Alcázar, Johanny Garcia, Miguel Urioste, N Malats, L Estudillo, Jesús Pérez-Pérez, Eloy Espín, F Marinello, M Kraft, Stefania Landolfi, B Pares, M Verdaguer
Abstract
BACKGROUND: Individuals with a non-syndromic family history of colorectal cancer are known to have an increased risk. There is an opportunity to prevent early-onset colorectal cancer (age less than 50 years) (EOCRC) in this population. The aim was to explore the proportion of EOCRC that is preventable due to family history of colorectal cancer. METHODS: This was a retrospective multicentre European study of patients with non-hereditary EOCRC. The impact of the European Society of Gastrointestinal Endoscopy (ESGE), U.S. Multi-Society Task Force (USMSTF), and National Comprehensive Cancer Network (NCCN) guidelines on prevention and early diagnosis was compared. Colorectal cancer was defined as potentially preventable if surveillance colonoscopy would have been performed at least 5 years before the age of diagnosis of colorectal cancer, and diagnosed early if colonoscopy was undertaken between 1 and 4 years before the diagnosis. RESULTS: Some 903 patients with EOCRC were included. Criteria for familial colorectal cancer risk in ESGE, USMSTF, and NCCN guidelines were met in 6.3, 9.4, and 30.4 per cent of patients respectively. Based on ESGE, USMSTF, and NCCN guidelines, colorectal cancer could potentially have been prevented in 41, 55, and 30.3 per cent of patients, and diagnosed earlier in 11, 14, and 21.1 per cent respectively. In ESGE guidelines, if surveillance had started 10 years before the youngest relative, there would be a significant increase in prevention (41 versus 55 per cent; P = 0.010). CONCLUSION: ESGE, USMSTF, and NCCN criteria for familial colorectal cancer were met in 6.3, 9.4, and 30.4 per cent of patients with EOCRC respectively. In these patients, early detection and/or prevention could be achieved in 52, 70, and 51.4 per cent respectively. Early and accurate identification of familial colorectal cancer risk and increase in the uptake of early colonoscopy are key to decreasing familial EOCRC.