Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients
Mei Yang, Libo Zhao, Xiaohui Wang, Chen Sun, Hengmiao Gao, Xiao‐Ling Wang, Suyun Qian
Abstract
159.96). Therefore, dosage adjustment was required according to the AST levels. The PopPK characteristics of linezolid in critically ill children were evaluated, and an optimal dosage regimen was constructed based on developmental PopPK/PD model and simulation. (This study has been registered in the Chinese Clinical Trial Registry under no. ChiCTR1900021386.).
Topics & Concepts
DosingMedicinePharmacokineticsLinezolidPopulationTherapeutic drug monitoringRegimenPharmacodynamicsPharmacologyNONMEMInternal medicineVancomycinEnvironmental healthBiologyBacteriaStaphylococcus aureusGeneticsAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in Bacteria