Intense 68Ga-FAPI-46 Activity in Lesions of Recurrent Ovarian Clear Cell Carcinoma That Were Negative on FDG PET/CT Study
Dheeratama Siripongsatian, Chetsadaporn Promteangtrong, Anchisa Kunawudhi, Peerapon Kiatkittikul, Chanisa Chotipanich
Abstract
ABSTRACT: A 55-year-old woman with recurrent ovarian clear cell carcinoma who underwent complete surgical staging and completed chemotherapy session approximately 7 months before. She presented with increased CA-125 levels. 68Ga-FAPI-46 PET showed significantly higher tumor-to-background contrast of recurrent intra-abdominal node metastases and distant metastases, which were undetectable in the 18F-FDG PET. These findings changed the patient management. Larger studies with comparisons with other imaging modalities are required to validate the diagnostic performance.
Topics & Concepts
MedicineChemotherapyRadiologyOncologyClear cellClear cell carcinomaInternal medicineOvarian carcinomaCarcinomaPositron emission tomographyClear-cell adenocarcinomaRadiation therapyClear cell renal cell carcinomaOvarian carcinomasComplete responsePathologyTreatment modalityComplete remissionEpitheliomaPeptidase Inhibition and AnalysisConnective tissue disorders researchEnzyme Structure and Function