Regulatory T cell therapy in solid organ transplantation: clinical applications and laboratory monitoring strategies
Minjeong Nam
Abstract
monitoring. This review provides a detailed overview of Treg mechanisms, ongoing clinical trials, and methodological approaches for evaluating their phenotype and function through cell-based, protein-based, and gene-based assays. In addition, it highlights key considerations for optimizing therapeutic efficacy and ensuring safety, with the ultimate aim of advancing Treg therapy toward routine clinical use in solid organ transplantation.
Topics & Concepts
MedicineCell therapyImmunotherapyImmunologyClinical trialImmune systemRegulatory T cellIntensive care medicineAdoptive cell transferFunction (biology)Translational researchT cellTherapeutic approachBioinformaticsTransplantationOrgan transplantationChimeric antigen receptorCell functionAdoptive immunotherapyImmunologic ToleranceRenal Transplantation Outcomes and TreatmentsT-cell and B-cell ImmunologyImmune Cell Function and Interaction