Design and synthesis of novel 3,4-dihydrocoumarins as potent and selective monoamine oxidase-B inhibitors with the neuroprotection against Parkinson’s disease
Li Liu, Yi Chen, Ruifeng Zeng, Yun Liu, Sai‐Sai Xie, Jinshuai Lan, Yue Ding, Yiting Yang, Jun Yang, Tong Zhang
Topics & Concepts
NeuroprotectionMonoamine oxidaseChemistryRotenonePharmacologyMPTPMonoamine oxidase BRasagilineIproniazidSelegilineIC50Parkinson's diseaseBiochemistryEnzymeIn vitroDiseaseMedicineInternal medicineMitochondrionParkinson's Disease Mechanisms and TreatmentsCholinesterase and Neurodegenerative DiseasesElectrochemical sensors and biosensors